ELDERBERRY: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews (2024)

Overview

Elderberry (Sambucus nigra) is the dark purple berry from the European elder tree. It has a long history of use for cold and flu.

Elderberry is a popular ingredient in supplements. It might affect the immune system, and also seems to have activity against viruses, including the flu.

Elderberry is commonly used for the common cold, flu, high cholesterol, and many other conditions, but there is no good scientific evidence to support most of these uses, with the possible exception of the flu. There is also no good evidence to support using elderberry for COVID-19.

Don't confuse elderberry with American Elder, Elderflower, or Dwarf Elder. These aren't the same and have different effects.

Uses & Effectiveness ?

Possibly Effective for

  • Flu (influenza). Taking a specific elderberry extract syrup (Sambucol, Nature's Way) seems to reduce flu symptoms when taken within 48 hours of the first symptoms. But it might not be helpful in some people, including those with lung conditions or children under 12 years of age.

There is interest in using elderberry for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.

Side Effects

When taken by mouth: Elderberry is commonly consumed in foods. Elderberry extract is possibly safe when taken for up to 12 weeks. There isn't enough reliable information to know if it is safe to use for longer than 12 weeks.

It is possibly unsafe to consume elder leaves or stems, or unripe or uncooked elderberries. Cooked elderberry seems to be safe, but raw and unripe fruit might cause nausea, vomiting, or severe diarrhea.

Special Precautions and Warnings

When taken by mouth: Elderberry is commonly consumed in foods. Elderberry extract is possibly safe when taken for up to 12 weeks. There isn't enough reliable information to know if it is safe to use for longer than 12 weeks.

It is possibly unsafe to consume elder leaves or stems, or unripe or uncooked elderberries. Cooked elderberry seems to be safe, but raw and unripe fruit might cause nausea, vomiting, or severe diarrhea. Children: Elderberry extract is possibly safe in children 5 years of age or older when taken by mouth for up to 3 days. There isn't enough reliable information to know if it is safe for children younger than 5 years of age to take elderberry. Unripe or uncooked elderberries are possibly unsafe. Don't give them to children.

Pregnancy and breast-feeding: There isn't enough reliable information to know if elderberry extract is safe to use when pregnant or breast-feeding. Stay on the safe side and stick to food amounts.

"Autoimmune diseases" such as multiple sclerosis (MS), lupus (systemic lupus erythematosus, SLE), rheumatoid arthritis (RA), or other conditions: Elderberry might cause the immune system to become more active. This could increase the symptoms of autoimmune diseases. If you have one of these conditions, it's best to avoid using elderberry.

Interactions ?

    Moderate Interaction

    Be cautious with this combination

  • Medications that decrease the immune system (Immunosuppressants) interacts with ELDERBERRY

    Elderberry can increase the activity of the immune system. Some medications, such as those used after a transplant, decrease the activity of the immune system. Taking elderberry along with these medications might decrease the effects of these medications.

Dosing

Elderberry fruit extracts have most often been used by adults in doses up to 1200 mg by mouth daily for 2 weeks. Elderberry is available in many different types of products, including syrups and mouth rinses. Speak with a healthcare provider to find out what type of product and dose might be best for a specific condition.

Don't consume green, unripe, uncooked elderberries. They contain toxins and can be poisonous.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circ*mstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.

ELDERBERRY: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews (2024)

FAQs

What medications cannot be taken with elderberry? ›

Because elderberry may stimulate the immune system, it could interfere with medications taken to suppress the immune system. These medications include corticosteroids (prednisone) and medications used to treat autoimmune diseases. People with organ transplants should also avoid elderberry.

What are the precautions for elderberries? ›

Special Precautions and Warnings

Elderberry extract is possibly safe when taken for up to 12 weeks. There isn't enough reliable information to know if it is safe to use for longer than 12 weeks. It is possibly unsafe to consume elder leaves or stems, or unripe or uncooked elderberries.

Are there negative side effects of elderberry? ›

The common side effects of taking raw elderberry plant products, such as fruit, flower, leaves, bark, or root include: Stomach problems. Nausea and vomiting. Diarrhea and constipation.

Is elderberry safe to take daily? ›

Elderberry supplements seem to have few risks when used daily for up to five days. The safety of its long-term use is unknown. Risks. Never eat or drink any product made from raw elderberry fruit, flowers, or leaves.

Which autoimmune diseases should avoid elderberry? ›

People who have autoimmune conditions such as multiple sclerosis (MS), rheumatoid arthritis, lupus, psoriasis, and inflammatory bowel disease should not use elderberry. Elderberry may boost the immune system, which can worsen autoimmune diseases.

Is elderberry bad for blood pressure? ›

Further studies found that rats that were fed foods containing polyphenols extracted from elderberry had reductions in blood pressure (25). Furthermore, elderberries may reduce levels of uric acid in the blood. Elevated uric acid is linked to increased blood pressure and negative effects on heart health (4, 26 ).

Is elderberry safe for your liver? ›

Exposure to elderberry could be responsible for either the initiation or progression of autoimmune liver disease in the setting of genetic predisposition and molecular mimicry. Therefore, obtaining a meticulous history pertaining to medications is warranted, with an emphasis on over-the-counter supplements.

What pairs well with elderberry? ›

Some common companion ingredients for elderberries include brown sugar, dates, dried figs, maple syrup, blackberries, raspberries, stone fruits, roasted nuts, scallops, vanilla, white wines, tawny ports, and coffee.

What is the toxin in elderberries? ›

They contain a cyanide-inducing glycoside. Eating a sufficient quantity of these cyanide-inducing glycosides can cause a toxic buildup of cyanide in the body and make you quite ill.

Who shouldn't take elderberry? ›

Children and pregnant or breastfeeding women shouldn't eat elderberries at all, since it's not known how the berries might affect them. Elderberry supplements can interfere with diabetes medications, laxatives and diuretics, so you shouldn't take elderberry supplements if you are on any of these medications.

Is elderberry safe for kidneys? ›

Cardiovascular disease risk biomarkers and liver and kidney function are not altered in postmenopausal women after ingesting an elderberry extract rich in anthocyanins for 12 weeks. J Nutr. 2009 Dec;139(12):2266-71. doi: 10.3945/jn.

Does elderberry affect the heart? ›

The berries and flowers of elderberry are packed with antioxidants and vitamins that may boost your immune system. They could help tame inflammation, lessen stress, and help protect your heart, too.

Does elderberry interact with any medications? ›

Elderberry has no known severe, serious, or moderate interactions with other drugs. Elderberry has mild interactions with at least 28 different drugs.

Should I take elderberry in the morning or at night? ›

Although there is no specific time of day to take elderberry, you'll maximize its benefits by using it consistently on a regular basis. You can choose whether to use it morning, afternoon or evening. It may be best to use elderberry for short periods of time to support healthy immune function, and then take a break.

What's the best form of elderberry to take? ›

You can choose from many forms, such as capsules, teas, lozenges, liquids and gummies. If you struggle with swallowing, you may prefer lozenges or gummies, whereas if you prefer to consume your supplement as a warm drink, tea will suit you. For quick consumption, an elderberry extract or pills will be the way to go.

Can you mix elderberry with anything? ›

If desired, you may mix elderberry liquid with water, fruit juice, yogurt, or a smoothie. Call your doctor if the condition you are treating with elderberry does not improve, or if you have a fever for more than 3 days or cold symptoms for more than 7 days.

Can I take Tylenol and elderberry at the same time? ›

Interactions between your drugs

No interactions were found between acetaminophen and Elderberry Gummies with Vitamin C and Zinc. However, this does not necessarily mean no interactions exist.

Can I take elderberry with lisinopril? ›

Interactions between your drugs

No interactions were found between Elderberry Immue Health and lisinopril.

Does elderberry interact with antidepressants? ›

No interactions were found between elderberry and Prozac.

References

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