Abstract
Rare sugar D-allulose prevents obesity; however, an excessive and continuous intake of D-allulose may induce weight increases in the liver and kidney without apparent pathological and functional abnormalities. Conversely, there has not been reported about how these parameters will change after cessation of D-allulose intake. In this study, effects of a 10-week D-allulose cessation on liver and kidneys weights and biomarkers were investigated in rats previously fed a D-allulose containing diet for 4 weeks. Wistar rats were fed a control diet (C, n=16) or a 3% D-allulose diet (DA, n=16) for 4 weeks, and then the half of rats in the C and DA subgroups were dissected, while the other half of rats were fed the control diet for 10 weeks (C-C and DA-C, n=8, respectively). At the end of the first 4 weeks period, halves of rats in each diet group were euthanized, and the serum, urine, liver, and kidneys were used for pathological and biochemical analyses. The remaining rats were also similarly treated at the end of latter 10 weeks treatment. At week 4, the relative weights of the liver and kidneys were higher in the DA group than in the C group, but these differences were disappeared by cessation of D-allulose. No abnormal parameters related to liver and kidneys functions were observed in the serum and urine. These findings suggested that D-allulose-induced increases in the liver and kidneys weights could be recovered to the normal levels by D-allulose cessation without accompanying functional and pathological abnormalities.
FAQs
It may protect against fatty liver
Studies in rats and mice have found that, in addition to preventing weight gain, allulose seems to reduce fat storage in the liver (11, 12 ). Hepatic steatosis, more commonly known as fatty liver, is strongly linked to insulin resistance and type 2 diabetes.
What is the effect of D-allulose feeding on the hepatic metabolomics profile in male wistar rats? ›
Wistar rats were fed an AIN-93G diet with/without 3% d-allulose for 4 weeks. Their liver samples were then collected and subjected to metabolomics analysis using CE-TOFMS and LC-TOFMS. The results showed that d-allulose induced significant increases in 42 metabolites and significant decreases in 21 metabolites.
Does allulose affect the kidneys? ›
Rare sugar D-allulose prevents obesity; however, an excessive and continuous intake of D-allulose may induce weight increases in the liver and kidney without apparent pathological and functional abnormalities.
Can allulose be metabolized? ›
D-Allulose can't be metabolized and in vivo converted into energy, but it plays an important role in the physiological activity of animals.
What is the downside of allulose? ›
The Drawbacks of Allulose
In addition, some research shows that allulose may promote the growth of certain bacteria associated with poor effects on gut health. In either case, allulose could cause GI symptoms of discomfort, gas or bloating similar to those with other sugar substitutes. Moderation is always the key.
What happens if you eat too much allulose? ›
However, like other poorly digested carbohydrates, too much allulose can lead to gastrointestinal discomfort. Two small studies in healthy adults reported gastrointestinal symptoms such as nausea, diarrhea, and abdominal pain after allulose consumption.
What foods help repair kidneys? ›
Fruits
- Açai berries. Açai (ah-sigh-EE) berries are small fruits that grow in clusters like grapes and have a center pit. ...
- Apples. Apples are rich in antioxidants and a good source of fiber and vitamin C. ...
- Citrus. ...
- Cherries. ...
- Pomegranates. ...
- Strawberries. ...
- Tomatoes.
Allulose is banned in Europe and Canada, possible carcinogen.
Why is allulose banned in Canada? ›
Health Canada's Food and Drug Regulations and the European Food Safety Authority have classified allulose as a novel food ingredient, but safety assessments have not been completed to set an approval rating in these areas (2,3).
Is D-allulose the same as allulose? ›
Allulose is also known as d-psicose, d-allulose, or pseudo-fructose.
The authors say that the amount you can eat without experiencing side effects is based on body weight. So, someone who weighs 132 pounds should be able to comfortably consume 24 grams of allulose in a single sitting and up to 54 grams per day (two teaspoons of allulose is 8 grams).
Which is better, allulose or stevia? ›
Allulose leads to a much lower rise in blood sugar and insulin compared to sugar, while stevia doesn't raise blood sugar at all in those with blood sugar levels already in normal range.
Is allulose cancerous? ›
If consumed in large quantities, allulose may cause some stomach discomfort, including gassiness, bloating and queasiness. That's true of most other artificial sweeteners, too. And contrary to some popular myths, the National Cancer Institute says research hasn't shown artificial sweeteners to cause cancer.
Can artificial sweeteners cause liver damage? ›
The liver plays a crucial role in metabolising various substances, including sugar and artificial sweeteners. The introduction of these sweeteners may lead to metabolic confusion, potentially contributing to liver dysfunction over time.
