Ginkgobiloba
There’s no conclusive evidence that Ginkgo biloba is efficacious in preventing or slowing dementia or cognitive decline.
Omega-3 fatty acidsupplements
Among the nutritional and dietary factors studied to prevent cognitive decline in older adults, the most consistent positive research findings are for omega-3 fatty acids, often measured as how much fish is consumed in the diet. However, several high-quality reviews have found no convincing evidence for the efficacy of omega-3 polyunsaturated fatty acid supplements in the treatment of mild-to-moderate Alzheimer’s disease.
Read more on the research of omega-3 fatty acid supplements.
VitaminE
Many laboratory and animal studies have investigated the role of vitamin E in the prevention and treatment of Alzheimer’s disease; evidence from human studies is much more limited.
A 2017 Cochrane systematic review found no evidence that vitamin E given to people with mild cognitive impairment prevents progression to dementia, or that it improves cognitive function in people with mild cognitive impairment or dementia due to Alzheimer’s disease. However, there is moderate quality evidence from a single study that it may slow functional decline in Alzheimer’s disease.
Curcumin
Preclinical studies have shown that curcumin targets inflammatory and antioxidant pathways as well as (directly) amyloid aggregation. However, the few clinical trials that have examined the effects of curcumin on Alzheimer’s disease are limited and inconsistent, making it difficult to draw conclusions about potential benefits.
B vitamins
Findings from short-term studies suggest that B-vitamin supplements (B12, B6, and folic acid) do not help cognitive functioning in adults ages 50 or older with or without dementia.
